Malonic Acid - Dr. Clark Information Center
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Is an industrial chemical. It is found in sprayed food, dentalware, water, cookware, dishes, utensils.

It also has an internal source. Tapeworm larvae and other parasites such as fasciolopsis buski, fasciola hepatica and paragonimus infect our tissues, releasing malonic and maleic acids.

Malonic acid is very damaging especially in cancer and other degenerative diseases because it interferes with respiration (the making of ATP in mitochondria). When our cells are accidentally fed t malonic acid, they mistake it for succinic acid because the molecules are "look-alikes." The Krebs cycle stalls. And because every step is dependent on the previous step the entire chain of metabolism, called respiration, stalls. It was known by 1909 that malonic acid is a severe respiratory inhibitor.

Maleic acid, part of the "M" family (malonic family) causes effusates which are seepages of body fluid into places where it does not belong. This "water accumulation" can take place in lung, abdomen or other other less common sites.

Methyl malonate is a serious kidney toxin and causes kidney failure. Removing it improves kidney function.

Scientists studied malonic acid, also called malonate, intensely for decades though never suspecting its true significance for humans. A lengthy and excellent review of malonate research has been published in Enzyme And Metabolic Inhibitors Vol. II (see previous footnote). Here is a partial list of topics reviewed.

  • Malonate inhibits uptake of glycine and alanine.
  • Malonate may chelate iron so it can’t be incorporated into hemoglobin.
  • Malonate inhibits healing.
  • Motility of sperm is reduced by malonate.
  • Bacterial phagocytosis by human neutrophils is depressed by malonate.
  • Malonate chelates calcium.
  • Malonate drops the resting potential of muscle.
  • Malonate causes air hunger (dyspnea).
  • Methyl malonate is toxic to the kidney.
  • Acetoacetyl Co A can transfer its Co A to malonic acid to make malonyl Co A. This could lead to acetoacetate buildup, namely ketonuria and possibly a block in fat utilization of even numbered carbon atoms, leaving odd numbered carbons to predominate.
  • Malonic acid reacts with aldehydes.
  • Thallium is chelated by malonic acid into a stable compound. (This could explain accumulation effect in a tumor.)
  • A color test for malonates is tetra hydroquinoline-N-propinal to form blue-violet compounds. It is sensitive to 0.01 mg malonate.
  • Malonate complexes with zinc and magnesium.
  • A fall in malate concentration due to malonate causes depletion of NADP.
  • Malonate induces ketonemia.
  • Malonate reduces oxygen uptake. Coenzyme Q10 is required to make ATP.
  • Malonate raises cholesterol.
  • D-malic acid complexes with malic dehydrogenase and NADH, but is enzymatically inactive.
  • Maleic acid is competitive inhibitor of succinic dehydrogenase.
  • Synergism between rotenone and malonate occurs in mitochondria.
  • Malonate causes oxidation of NADH and cytochromes.
  • Rats can convert malonate to acetate in the presence of malonyl Co A.
  • Malonate reduces survival of infected animals.
  • Malonate fed to dogs is recovered as methyl malonate in urine.
  • Malonate can pick up an amino group from glutamine.
  • Hemolysis of red blood cells may be caused by malonyl dialdehyde (MDA), a derivative of malonic acid.
  • Malonate catalyses renal glutaminase; with less glutamine uric acid levels fall.
  • Malic acid (apple juice) is the best antidote to malonic acid. (But commercial sources contain patulin which depletes cellular glutathione.)
  • Malonic acid is present in urine.
  • Malonate depresses the reduction of GSSG to glutathione.
  • Malonate inhibits protoporphyrin formation 32%.
  • Malonate inhibits insulin stimulation of muscle respiration.
  • Malonate inhibits acetylcholine synthesis.
  • Mycobacterium phlei respiration is stimulated by malonate. (All schizophrenia cases I see test positive to this bacterium in the brain!)
  • Malonate is put into soy sauce in Japan.
  • Malonate stimulates Entamoeba histolytica growth.
  • Malonate inhibits phosphate entry into cells.
  • Potassium transport into cells is inhibited by malonate.
  • Malonate causes systemic acidosis.
  • Calcium and iron transport by rat duodenum is severely reduced by malonate.
  • Malonate inhibits pyruvate oxidation.
  • Malonate causes increased utilization of glucose due to the Pasteur effect of a blocked Krebs cycle.
  • Lactic acid formation is increased with malonate inhibition of respiration.
  • Glycolysis is stimulated by malonate.
  • Malonate has different effects on different tissues.
  • Much less glucose goes to form amino acids and proteins in the presence of malonate.
  • Malonate induces the appearance of the pentose phosphate shunt.
  • Malonate diverts fatty acid metabolism to acetoacetate.
  • Malonate increases the formation of fatty acids up to 10-fold.
  • Maleic acid is a potent inhibitor of urinary acidification.
  • Malonate inhibits oxidation of fatty acids.
  • Malonate fed to dogs produces acetoacetate, acetone and alcohol.
  • Malonate can reduce the concentration of magnesium and calcium to 25% or 50%.
  • The methyl derivative of malonate depresses renal function.
  • Malonic acid can form malonyl coenzyme A, which is very stable, thereby depleting the system of coenzyme A.
    (Coenzyme A has a nucleic acid base, adenine, plus pantothenic acid and sulfur in its makeup. You will have an increased need for these nutrients.)
  • Malonate inhibits urea formation by reducing the supply of oxaloacetate.
  • Malonate inhibits cell cleavage (the formation of a wall between 2 dividing cells).
  • Benzaldehyde reacts with malonic acid.

The body detoxifies Malonic acid in this way:



  • Drink parsley water boiled 5 minutes, 2 cups in divided doses daily
  • Vitamin B12 - 6 mg
  • Folic acid - 25 mg
  • Increase Vitamin C (or rosehips) to double amounts

Continue with Disease & Protocols

(Taken from excerpts of Dr. Clark’s books: "The Cure of all Advanced Cancers" and "The Prevention of all Cancer")

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